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  • Notify your physician immediately if you experience nausea, vomiting, headache, or visual changes, especially during the first 8 weeks of treatment. These symptoms could indicate that you need a dosage adjustment or that you need to stop using Zorbtive.
  • Contact your physician immediately if you have Prader-Willi syndrome and develop signs of lung or breathing problems such as shortness of breath, coughing, or new or increased snoring. Rare cases of serious breathing problems have been reported in patients with Prader-Willi syndrome taking Zorbtive.
  • Zorbtive is a form of the naturally occurring human growth hormone. Human growth hormone is important in the body for the growth of bones and muscles.
  • Zorbtive is used to treat children and adults with growth failure because of a deficiency of growth hormone, chronic kidney failure, Turner syndrome, and sometimes when the cause of short stature is not known. The Serostim brand of Zorbtive is used to prevent severe weight loss that can occur with the acquired immunodeficiency syndrome (AIDS). The Zorbtive brand of somatropin is used in the treatment of short bowel syndrome.
  • Zorbtive may also be used for purposes other than those listed in this medication guide.




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  • Use Zorbtive exactly as directed by your physician. If you NOT understand these directions, ask your physician, nurse, or pharmacist to explain them to you.
  • Somatropin can be injected subcutaneously (under the skin). Humatrope and Saizen can also be injected intramuscularly (into the muscle). If you are administering this medication at home, your physician will give you detailed instructions on how to mix the solution and give an injection. Rotate injection sites as directed by your physician. NOT inject this medication if you are unsure how.
  • Vials of somatropin may require mixing before injection. Gently swirl the bottle after adding the diluent. NOT shake. Because somatropin is a protein, shaking the vial of solution may result in a cloudy solution that should not be used. NOT inject any somatropin product that is not completely dissolved, or that is discolored or cloudy immediately after mixing or after removal from the refrigerator. Occasionally, mixed solution that has been refrigerated may contain small, colorless particles. This is not harmful. Allow the solution to come to room temperature and gently swirl the vial. If the solution is cloudy, the medication must not be injected.
  • Consult your physician, pharmacist, or the package insert regarding storage conditions and how long the medication may be stored after mixing.
  • The Nutropin Depot form of somatropin is only injected once or twice monthly. Follow your physician's instructions.
  • Never reuse a needle or syringe. Dispose of all needles and syringes in an appropriate, puncture resistant disposal container.
  • your physician may want you to have blood tests or other medical evaluations during treatment with Zorbtive to monitor progress and side effects.
  • Notify your physician immediately if you experience nausea, vomiting, headache, or visual changes, especially during the first 8 weeks of treatment. These symptoms could indicate that you need a dosage adjustment or that you need to stop using Zorbtive.
  • Use the Norditropin cartridges only with the corresponding color-coded NordiPen. The color-coding system is designed to deliver the appropriate dose of medication.
  • Many somatropin products are available as cartridges for pen delivery systems. The pen delivery systems may not be interchangeable. Use only the pen delivery system provided with your particular product. Ask your physician or pharmacist if you are unsure if the system is compatible.
  • NOT allow any medication kept in the refrigerator to freeze. If the medicine does freeze, NOT use it.
  • Read the information that comes with the product for specific storage instructions, before and after mixing. Or ask your pharmacist about proper storage.

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  • Contact your physician immediately if you have Prader-Willi syndrome and develop signs of lung or breathing problems such as shortness of breath, coughing, or new or increased snoring. Rare cases of serious breathing problems have been reported in patients with Prader-Willi syndrome taking Zorbtive.
  • If you experience any of the following uncommon but serious side effects, stop using Zorbtive and seek emergency medical attention or notify your physician immediately:
    -- an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); or
    -- nausea, vomiting, headache, or visual changes.
  • Other side effects may also occur, although they are not common. Notify your physician if you experience
    -- headache;
    -- muscle pain or weakness; or
    -- mild symptoms of hyperglycemia such as increased thirst, increased urination, or sugar in the urine.
  • Side effects other than those listed here may also occur. Talk to your physician about any side effect that seems unusual or that is especially bothersome.

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