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  • Use caution when driving, operating machinery, or performing other hazardous activities. Provigil may affect your judgment, thinking, or motor skills. If you experience any of these effects, avoid hazardous activities.
  • It is best to avoid alcohol while taking Provigil. Alcohol may have altered or increased effects while taking Provigil.
  • Provigil may decrease the effects of hormonal methods of birth control including birth control pills and depot and implantable formulations (e.g., Norplant, Depo-Provera). Use a second, nonhormonal form of birth control while taking Provigil, and for one month after stopping Provigil, if prevention of pregnancy is desired.
  • Provigil may be habit forming. You should discuss the abuse and dependence potential of Provigil with your physician. NOT stop taking Provigil without first talking to your physician. your physician may want to gradually lower the dose of the medication before stopping treatment.
  • The exact way that Provigil works is not known.
  • Provigil is used to improve wakefulness in patients with excessive daytime sleepiness associated with narcolepsy.
  • Provigil may also be used for purposes other than those listed in this medication guide.




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  • Take Provigil exactly as directed by your physician. If you NOT understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.
  • Take each dose with a full glass of water.
  • Provigil can be taken with or without food.
  • Provigil is usually taken in the morning. Follow your physician's instructions.
  • Provigil may be habit forming. You should discuss the abuse and dependence potential of Provigil with your physician. NOT stop taking Provigil without first talking to your physician. your physician may want to gradually lower the dose of the medication before stopping treatment.
  • Store Provigil at room temperature away from moisture and heat.

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  • If you experience any of the following uncommon but serious side effects, stop taking Provigil and seek emergency medical attention or contact your physician immediately:
    -- an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
    -- irregular heartbeats;
    -- low or high blood pressure; or
    -- shortness of breath.
  • Other, less serious side effects may be more likely to occur. Continue to take Provigil and talk to your physician if you experience
    -- headache;
    -- infection;
    -- nausea, decreased appetite, or diarrhea;
    -- chills;
    -- dry mouth;
    -- runny nose;
    -- sore throat;
    -- nervousness;
    -- anxiety;
    -- dizziness;
    -- insomnia;
    -- depression; or
    -- numbness or tingling.
  • Provigil may be habit forming. You should discuss the abuse and dependence potential of Provigil with your physician. NOT stop taking Provigil without first talking to your physician. your physician may want to gradually lower the dose of the medication before stopping treatment.
  • Side effects other than those listed here may also occur. Talk to your physician about any side effect that seems unusual or that is especially bothersome.

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