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  • NOT take Symbyax if you are taking or have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) during the last 2 weeks. Serious, and sometimes fatal, reactions have occurred when these medicines have been used together. Also, NOT take Symbyax if you are taking thioridazine (Mellaril). Dangerous, even fatal irregular heartbeats may occur if these medicines are taken together. You must wait 5 weeks after stopping Symbyax before taking thioridazine (Mellaril).
  • NOT stop taking Symbyax without first talking to your physician. It may take several weeks before you start to feel better.
  • Contact your physician immediately if you experience fever, sweating, severe muscle stiffness (rigidity), confusion, or fast or irregular heart beats. These could be symptoms of a potentially fatal side effect called Neuroleptic Malignant Syndrome (NMS).
  • Contact your physician immediately if you experience uncontrollable movements of the mouth, tongue, cheeks, jaw, arms, or legs.
  • Use caution when driving, operating machinery, or performing other hazardous activities. Symbyax may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.
  • Dizziness may be more likely to occur when you rise from a sitting or lying position. Rise slowly to prevent dizziness and a possible fall.
  • Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking Symbyax.
  • There is an increased chance of becoming overheated while taking Symbyax. Drink plenty of fluid and use caution in hot weather and during exercise.
  • Fluoxetine is in a class of drugs called selective serotonin reuptake inhibitors. Fluoxetine affects chemicals in the brain that may become unbalanced and cause depression, mood disturbances, or other psychological symptoms.
  • Olanzapine is an antipsychotic medication. It works by changing the actions of chemicals in the brain.
  • Together, fluoxetine and olanzapine are used to treat depression associated with bipolar disorder.
  • Symbyax may also be used for purposes other than those listed in this medication guide.




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  • Take Symbyax exactly as directed by your physician. If you NOT understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.
  • Take each dose with a full glass of water.
  • Symbyax can be taken with or without food.
  • Try to take Symbyax at the same time each day.
  • NOT stop taking Symbyax without first talking to your physician. It may take several weeks before you start to feel better.
  • It is important to take Symbyax regularly to get the most benefit.
  • your physician may want to perform tests or schedule appointments to monitor your treatment with Symbyax.
  • Store Symbyax at room temperature away from moisture and heat.

    Symbyax side effects

  • Contact your physician immediately if you experience fever, sweating, severe muscle stiffness (rigidity), confusion, or fast or irregular heart beats. These could be symptoms of a potentially fatal side effect called Neuroleptic Malignant Syndrome (NMS).
  • Contact your physician immediately if you experience uncontrollable movements of the mouth, tongue, cheeks, jaw, arms, or legs.
  • If you experience any of the following serious side effects, stop taking Symbyax and contact your physician immediately or seek emergency medical treatment:
    -- an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
    -- an irregular heartbeat or pulse;
    -- low blood pressure (dizziness, weakness);
    -- high blood pressure (severe headache, blurred vision);
    -- chills or fever;
    -- unusual bleeding or bruising;
    -- a rash or hives.
  • If you experience any of the following less serious side effects, continue taking Symbyax and talk to your physician:
    -- headache, tremor, nervousness, or anxiety;
    -- difficulty concentrating;
    -- nausea, diarrhea, dry mouth, or changes in appetite or weight;
    -- weakness;
    -- increased sweating;
    -- sleepiness or insomnia; or
    -- decreased sex drive, impotence, or difficulty having an orgasm.
  • Side effects other than those listed here may also occur. Talk to your physician about any side effect that seems unusual or that is especially bothersome.

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