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Seasonale does not provide protection from sexually transmitted diseases--including HIV and AIDS. Using a condom is the only way to protect yourself from these diseases.
Take one pill every day at the same time, no more than 24 hours after the last dose. Try to take the pills at a time that you will remember every day--for example just before bed, with a meal, or first thing in the morning.
  • Avoid smoking cigarettes while taking ethinyl estradiol and levonorgestrel. Smoking greatly increases the risk of heart attack, stroke, and blood clot formation.
  • Follow your physician's instructions about using a second form of birth control when you first start taking ethinyl estradiol and levonorgestrel, when you are taking antibiotics or other medications, or if you miss a pill. If you are unsure what to do in any of these cases, talk to your pharmacist, nurse, or doctor about how to ensure that you will not become pregnant.
  • Ethinyl estradiol and levonorgestrel are hormones that affect the ovulatory and menstrual cycle of women. Ethinyl estradiol and levonorgestrel prevent ovulation (the release of an egg from an ovary), therefore preventing the possibility of pregnancy. Seasonale may also inhibit pregnancy by causing the cervical mucous to thicken, which makes it harder for sperm to move toward the uterus, and reducing the likelihood of attachment of a fertilized egg to the uterus.
  • The extended-cycle formulation of Seasonale has a 91-day treatment cycle, resulting in 4 menstrual periods per year.
  • Seasonale is used to prevent pregnancy.
  • Seasonale may also be used for purposes other than those listed in this medication guide.




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  • Take Seasonale exactly as directed by your physician. If you NOT understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.
  • The extended-cycle form of Seasonale involves a 91-day treatment cycle resulting in 4 menstrual periods per year (which occurs when you are taking the 7 white pills).
  • An increase in bleeding or spotting between periods (compared to taking a standard 21- or 28-day birth control pill cycle) is expected to occur. During the first cycle of pills, about 1 in 3 women may have 20 or more days of unplanned bleeding or spotting. This tends to decrease during later cycles. Treatment with Seasonale should not be stopped due to spotting or bleeding. If the spotting continues for more than 7 consecutive days or if the bleeding is heavy, contact your healthcare provider.
  • Take the first pill in a package on the first Sunday after your period begins, even if you are still bleeding. If your period starts on Sunday, take the first pill that day. Use another form of birth control anytime you have sex for the first 7 days you take the pills.
    Take one pill every day at the same time, no more than 24 hours after the last dose. Try to take the pills at a time that you will remember every day--for example just before bed, with a meal, or first thing in the morning. Taking the pill at night may help to reduce nausea or headache, which may be side effects.
  • Your period should occur during the 7 days you are taking the white pills (these pills are inactive and NOT contain hormones). If it doesn't, have a pregnancy test before beginning a new package of pills.
  • After taking the last white pill from a pack, start a new pack the very next day. NOT skip any days.
  • Follow your physician's instructions about using a second form of birth control when you first start taking ethinyl estradiol and levonorgestrel, when you are taking antibiotics or other medications, or if you miss a pill. If you are unsure what to do in any of these cases, talk to your pharmacist, nurse, or doctor about how to ensure that you will not become pregnant.
  • Store Seasonale at room temperature away from moisture and heat.

    Seasonale side effects

  • If you experience any of the following serious side effects, stop taking Seasonale and seek emergency medical attention or contact your physician immediately:
    -- an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
    -- possible blood clot in the lung (shortness of breath, coughing up blood, or pain in the chest); the leg (pain, redness, swelling, or numbness of the leg); or the eye (partial or complete loss of vision);
    -- chest pain or heaviness in the chest (possible heart attack);
    -- severe headache or vomiting, dizziness or fainting, vision or speech disturbances, weakness or numbness in an arm or leg (may indicate a stroke);
    -- breast lumps;
    -- possible liver problems (yellowing of the skin or eyes, nausea, abdominal pain or discomfort, unusual bleeding or bruising, severe fatigue).
  • Other, less serious side effects may also occur. Continue to take Seasonale and talk to your physician if you experience
    -- breakthrough bleeding or spotting;
    -- headache;
    -- nausea or vomiting;
    -- breast tenderness;
    -- depression;
    -- changes in weight or appetite;
    -- changes in skin color; or
    -- changes in fit of contact lenses.
  • Side effects other than those listed here may also occur. Talk to your physician about any side effect that seems unusual or that is especially bothersome.

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