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  • Over-the-counter omeprazole (Prilosec OTC) should be taken once every 24 hours for 14 days. Treatment may be repeated every 4 months if needed. NOT take more than one tablet per day or repeat treatment more often than every 4 months. If your condition does not improve or if it appears to worsen, contact your healthcare provider.
  • NOT stop taking omeprazole even if you begin to feel better. Your symptoms may improve before the condition is fully treated.
  • Omeprazole decreases the amount of acid produced in the stomach.
  • Omeprazole is used to treat ulcers, gastroesophageal reflux disease (GERD or heartburn), and other conditions involving excessive stomach acid production.
  • Omeprazole may also be used for purposes other than those listed in this medication guide.




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  • Take omeprazole exactly as directed by your physician. If you NOT understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.
  • Take each dose with a full glass (8 ounces) of water.
  • Omeprazole is usually taken before a meal. Follow your physician's instructions.
  • NOT crush, chew, or break the over-the-counter omeprazole tablets (Prilosec OTC). Swallow them whole.
  • If you have difficulty swallowing, the prescription omeprazole capsules can be opened and the contents sprinkled onto a tablespoonful of applesauce. The pellets should be mixed with the applesauce and then swallowed immediately. The applesauce should not be hot and should be soft enough to be swallowed without chewing. The pellets should not be chewed or crushed. The pellet/applesauce mixture should not be stored for later use. Follow with a drink of water.
  • Over-the-counter omeprazole (Prilosec OTC) should be taken once every 24 hours for 14 days. Treatment may be repeated every 4 months if needed. NOT take more than one tablet per day or repeat treatment more often than every 4 months. If your condition does not improve or if it appears to worsen, contact your healthcare provider.
  • It is important to take omeprazole regularly to get the most benefit.
  • NOT stop taking omeprazole even if you begin to feel better. Your symptoms may improve before the condition is fully treated.
  • Store omeprazole at room temperature away from moisture and heat.

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  • If you experience an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives), stop taking omeprazole and seek emergency medical attention.
  • Other, less serious side effects may be more likely to occur. Continue to take omeprazole and talk to your physician if you experience
    -- drowsiness, dizziness, or headache;
    -- diarrhea, increased gas, or bloating; or
    -- itching.
  • Side effects other than those listed here may also occur. Talk to your physician about any side effect that seems unusual or that is especially bothersome.

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