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  • NOT take HCTZ and irbesartan if you are pregnant or planning a pregnancy. When used during the second and third trimesters of pregnancy, irbesartan can cause injury and even death to the developing baby. Notify your physician immediately if you think you might be pregnant.
  • Use caution when driving, operating machinery, or performing other hazardous activities. HCTZ (hydrochlorothiazide) and irbesartan may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Also use caution when rising from a sitting or lying position.
  • Stop taking HCTZ and irbesartan and contact your physician if lightheadedness or fainting occurs.
  • Use alcohol cautiously. Alcohol may increase the drowsiness and dizziness that may occur while you are taking an HCTZ and irbesartan.
  • Avoid prolonged exposure to sunlight. HCTZ and irbesartan may increase the sensitivity of your skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable.
  • Irbesartan is an angiotensin II receptor inhibitor, also called angiotensin II receptor antagonist, and is used to treat hypertension (high blood pressure).
  • HCTZ is a thiazide diuretic (water pill). It increases the amount of water and salt you lose in your urine and decreases edema (swelling or fluid retention).
  • Together, HCTZ and irbesartan are used to reduce hypertension (high blood pressure).
  • HCTZ and irbesartan may also be used for purposes other than those listed in this medication guide.




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    HCTZ - Drug dosage. Dosage information on HCTZ

  • Take HCTZ and irbesartan exactly as directed by your physician. If you NOT understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.
  • Take each dose with a full glass of water.
  • HCTZ and irbesartan can be taken with or without food.
  • Stop taking HCTZ and irbesartan and contact your physician if lightheadedness or fainting occurs.
  • NOT stop taking this medication without first talking to your physician. If you stop taking this medication suddenly, your condition could become worse.
  • Store HCTZ and irbesartan at room temperature away from moisture and heat.

    HCTZ side effects

  • If you experience any of the following serious side effects, stop taking this medication and call your physician immediately or seek emergency medical treatment:
    -- an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
    -- fast heartbeats;
    -- little or no urine;
    -- unusual fatigue, abnormal bleeding or bruising;
    -- yellow skin or eyes;
    -- confusion; or
    -- fainting.
  • Other, less serious side effects may be more likely to occur. Continue to take the medication and talk to your physician if you experience
    -- dizziness;
    -- nausea or upset stomach;
    -- diarrhea;
    -- headache;
    -- cough;
    -- muscle pain or cramps;
    -- rash; or
    -- anxiety or nervousness.
  • Side effects other than those listed here may also occur. Talk to your physician about any side effect that seems unusual or that is especially bothersome.

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