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  • A small number of people who have taken Glucophage have developed a serious condition called lactic acidosis that has been fatal in up to 50% of cases. Lactic acidosis has occurred most often in people whose kidneys were not working properly. Liver problems may also increase the risk of developing lactic acidosis. Stop taking Glucophage and call your physician immediately if you experience a feeling of general discomfort or sickness; weakness; sore or aching muscles; trouble breathing, unusual drowsiness, dizziness or lightheadedness; unusual or unexplained stomach upset (after the initial stomach upset that may occur at the start of therapy with Glucophage); or the sudden development of a slow or irregular heartbeat. These may be signs of lactic acidosis.
  • Avoid excessive alcohol intake while taking Glucophage. Together, alcohol and Glucophage may increase the risk of lactic acidosis and hypoglycemia.
  • Glucophage does not usually cause hypoglycemia (low blood sugar). Nevertheless, hypoglycemia may occur, as a result of skipped meals, excessive exercise, or alcohol consumption. Know the signs and symptoms of low blood sugar, which include hunger, headache, drowsiness, weakness, dizziness, a fast heartbeat, sweating, tremor, and nausea. Carry candy or glucose tablets to treat episodes of low blood sugar.
  • Glucophage is used to regulate blood glucose (sugar) levels. Glucophage works in three ways: first, it reduces the amount of glucose produced by your liver; second, it reduces the amount of glucose absorbed from food through your stomach; and third, it makes the insulin that your body produces work better to reduce the amount of glucose already in your blood.
  • Glucophage is used to treat non-insulin-dependent diabetes mellitus (NIDDM or Type II diabetes).
  • Glucophage may also be used for purposes other than those listed in this medication guide.




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    Glucophage - Drug dosage. Dosage information on Glucophage

  • Take Glucophage exactly as directed by your physician. If you NOT understand these directions, ask your pharmacist, nurse, or doctor to explain the instructions to you.
  • Take each dose with a full glass of water.
  • Take Glucophage with a meal to reduce nausea, diarrhea, and upset stomach that may occur with Glucophage therapy. These symptoms may be more likely to occur during the first few weeks of therapy.
  • A decrease in vitamin B12 may also occur during Glucophage therapy. your physician may want to monitor your blood levels of vitamin B12 and you may need to take B12 supplements. A vitamin B12 deficiency may rarely cause anemia.
  • your physician may want to monitor your blood sugar control and other factors with regularly scheduled blood tests.
  • Occasionally, inactive ingredients in the Glucophage extended-release (Glucophage XR) tablets may pass through your body undissolved and appear in the stool as a soft mass. This is not harmful, and the medication has been absorbed by your body.
  • Store Glucophage at room temperature away from moisture and heat.

    Glucophage side effects

  • Stop taking Glucophage and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives).
  • A small number of people who have taken Glucophage have developed a serious condition called lactic acidosis that has been fatal in up to 50% of cases. Lactic acidosis has occurred most often in people whose kidneys were not working properly. Liver problems may also increase the risk of developing lactic acidosis. Stop taking Glucophage and call your physician immediately if you experience a feeling of general discomfort or sickness; weakness; sore or aching muscles; trouble breathing, unusual drowsiness, dizziness or lightheadedness; unusual or unexplained stomach upset (after the initial stomach upset that may occur at the start of therapy with Glucophage); or the sudden development of a slow or irregular heartbeat. These may be signs of lactic acidosis.
  • Other, less serious side effects may be more likely to occur. Continue to take Glucophage and talk to your physician if you experience
    -- nausea, vomiting, abdominal pain, or diarrhea at the start of therapy;
    -- abdominal bloating or increased gas production; or
    -- decreased appetite or changes in taste (metallic taste in your mouth).
  • Side effects other than those listed here may also occur. Talk to your physician about any side effect that seems unusual or that is especially bothersome.

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