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  • Fentanyl topical should not be used to treat acute or post-operative pain. Fentanyl topical is used to treat chronic pain.
  • Use caution when driving, operating machinery, or performing other hazardous activities. Fentanyl may cause drowsiness or fatigue. If you experience drowsiness or fatigue, avoid these activities.
  • Also avoid alcohol, sleeping pills, tranquilizers, sedatives, and antihistamines. These medications also may cause dangerous sedation.
  • Fentanyl topical can also cause constipation. Drink plenty of water (six to eight full glasses a day) to lessen this side effect. Increasing the amount of fiber in your diet can also help to alleviate constipation.
  • Never use more fentanyl than is prescribed for you. If your pain is not being adequately treated, talk to your physician.
  • Fentanyl is in a class of drugs called narcotic analgesics. It relieves pain.
  • Fentanyl topical patches are used to treat chronic pain that cannot be controlled by less potent pain relievers.
  • Fentanyl topical may also be used for purposes other than those listed in this medication guide.




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  • Use fentanyl topical exactly as directed by your physician. If you NOT understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.
  • Apply the patch to a flat, dry, area such as the chest, back, side, or upper arm. Any hair on the application site should be clipped short but not shaved. Avoid areas that are irritated or otherwise damaged.
  • If the application site must be washed before the patch is applied, use clear water only. NOT use soaps, oils, lotions, alcohol, or other chemicals. Washing with these substances could change how much of the drug gets absorbed through the skin, which could be dangerous. Allow the skin to dry completely before applying the patch.
  • Apply the patch as directed. Press the patch firmly with the palm of your hand for 30 seconds making sure that the patch is sticking, especially around the edges. Each patch is worn for 72 hours.
  • After removing the patch, press the sticky side to itself and dispose of the system in the toilet. If another patch is required, apply it to a different skin site.
  • NOT cut or otherwise damage the patch, and NOT apply any patch that has been cut or damaged.
  • Never use more of this medication than is prescribed for you. Too much fentanyl could be very harmful.
  • Increase the amount of fiber and water in your diet to prevent constipation.
  • NOT share this medication with anyone else. Keep it out of the reach of children and pets.
  • Store fentanyl topical at room temperature away from moisture and heat.

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  • If you experience any of the following serious side effects, stop using fentanyl topical and seek emergency medical attention:
    -- an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
    -- slow, weak breathing;
    -- seizures;
    -- cold, clammy skin;
    -- severe weakness or dizziness; or
    -- unconsciousness.
  • Other, less serious side effects may be more likely to occur. Continue to use fentanyl topical and talk to your physician if you experience
    -- constipation;
    -- dry mouth, nausea, vomiting, or decreased appetite;
    -- dizziness or lightheadedness;
    -- drowsiness or fatigue;
    -- muscle twitches;
    -- sweating;
    -- itching;
    -- decreased urination; or
    -- decreased sex drive.
  • Fentanyl is habit forming. NOT stop using it suddenly.
  • Side effects other than those listed here may also occur. Talk to your physician about any side effect that seems unusual or that is especially bothersome.

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