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  • Avoid prolonged exposure to sunlight. Differin topical may increase the sensitivity of your skin to sunlight. Use a sunscreen and wear protective clothing when sun exposure is unavoidable.
  • NOT use Differin on sunburned, windburned, dry, chapped, or irritated skin or on open wounds.
  • Avoid abrasive, harsh, or drying soaps and cleansers while using Differin topical.
  • Differin is a compound similar to vitamin A. It helps the skin to renew itself more quickly and therefore reduces pimple and blackhead formation.
  • Differin topical is used to treat acné
  • Differin topical may also be used for purposes other than those listed in this medication guide.




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  • Use Differin topical exactly as directed by your physician. If you NOT understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.
  • Wash your hands before and after applying this medication.
  • Clean and dry the area to which you will apply Differin topical. Apply the medication to the affected area.
  • When applying Differin topical, avoid your eyes, the inside of your nose and mouth, your lips, and areas where the skin is broken to prevent excessive irritation. If you get medication in any of these areas, rinse it off with water.
  • NOT cover the affected area after applying Differin topical. Doing so could cause too much medicine to be absorbed by your body and could be harmful.
  • Differin topical is usually applied once daily at bedtime.
  • It may take 8 to 12 weeks or more to see the effects of this drug. NOT stop using Differin topical if you NOT see results immediately. During the early weeks of therapy, your acné may appear worse as previously unseen lesions begin to erupt. This is a temporary effect.
  • If you experience excessive burning, dryness, or irritation ask your physician about using Differin every other day or only a few days a week.
  • If you have dark skin and you notice a change in your skin color, contact your physician.
  • Store Differin topical at room temperature away from moisture and heat.

    Differin side effects

  • Serious side effects are not likely to occur. Stop using Differin topical and seek emergency medical attention if you experience an allergic reaction (shortness of breath; closing of your throat; swelling of your lips, face, or tongue; or hives).
  • You may experience some burning, warmth, stinging, tingling, itching, redness, dryness, peeling, or irritation while you are using Differin topical. If these side effects are excessive, ask your physician about using Differin every other day or only several days a week. These side effects should decrease after the first few weeks of treatment.
  • If you notice a change in your skin color, contact your physician.
  • Side effects other than those listed here may also occur. Talk to your physician about any side effect that seems unusual or that is especially bothersome.

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