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  • Before using Apokyn tell your physician if you are taking granisetron (Kytril), ondansetron (Zofran), dolasetron (Anzemet), palonosetron (Aloxi) or alosetron (Lotronex). These types of drugs can cause extremely low blood pressure in people using Apokyn.
  • Apokyn may cause drowsiness, dizziness, or fainting. NOT drive a car, operate machinery, or do anything that might put you at risk of getting injured until you know how Apokyn affects you. Tell your physician if you get dizzy or faint while taking Apokyn.
  • Before using Apokyn tell your physician if you are receiving any drugs to treat nausea and vomiting or irritable bowel syndrome.
  • Apokyn stimulates certain chemical receptors in your body. Increased stimulation of these receptors may help improve motor function in patients with Parkinson's disease.
  • Apokyn is used, as needed, by injection to treat the loss of control of body movements in people with advanced Parkinson's disease.
  • Apokyn may also be used for purposes other than those listed in this medication guide.




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  • Use Apokyn exactly as directed by your physician. If you NOT understand the directions, ask your pharmacist, nurse, or doctor to explain them to you.
  • Read the detailed 'Instructions For Use' included with the Apokyn product. NOT inject Apokyn unless you and your care giver have been shown how to administer Apokyn and understand all the directions. Talk to your physician if NOT understand something.
  • Apokyn should only be administered subcutaneously.
  • Choose an injection site on your stomach area, upper arm, or upper leg to inject Apokyn. Change the injection site each time you use Apokyn.
  • NOT inject Apokyn into an area of the skin that is sore, red, infected or damaged.
  • Only use Apokyn that is clear and colorless. NOT inject Apokyn that is cloudy, green, or contains particles.
  • NOT change your dose of Apokyn or use it more often unless your physician has told you to.
  • your physician may prescribe a medication called an antiemetic to take while you are using Apokyn. Antiemetics help lessen the symptoms of nausea and vomiting that can occur while using Apokyn.
  • Store Apokyn at room temperature away from moisture and heat. Syringes of Apokyn can be filled from the ampules the night before use and stored in the refrigerator until the next day.

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  • If you experience any of the following side effects, stop taking Apokyn and seek emergency medical attention or contact your physician immediately:
    -- an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
    -- irregular heartbeats;
    -- severe vomiting;
    -- chest pain; or
    -- muscle cramps or seizures.
  • Other side effects may be more likely to occur. Continue to take Apokyn and talk to your physician if you experience:
    -- dizziness;
    -- hallucinations;
    -- depression;
    -- headaches;
    -- injection site reactions;
    -- sleepiness or falling asleep while doing things during the day;
    -- falling down;
    -- sudden uncontrolled movements;
    -- nausea and vomiting; or
    -- diarrhea or constipation.
  • Side effects other than those listed here may also occur. Talk to your physician about any side effect that seems unusual or that is especially bothersome.

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